IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
Background: IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown. Objective: We hypothesized that IL-13 - induced inflammatory changes in the lung were dependent in part on IL-5 and eotaxin, two eosinophil-selective cytokines. Methods: Recombinant murine IL-13 was repeatedly administered to the lung by intranasal delivery until the characteristic features...[Show more]
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|Source:||Journal of Allergy and Clinical Immunology|
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