Pope, Samuel; Brandt, Eric; Mishra, Anil; Hogan, Simon; Zimmermann, Nives; Matthaei, Klaus; Foster, Paul S; Rothenberg, Marc E
Background: IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown. Objective: We hypothesized that IL-13 - induced inflammatory changes in the lung were dependent in part on IL-5 and eotaxin, two eosinophil-selective cytokines. Methods: Recombinant murine IL-13 was repeatedly administered to the lung by intranasal delivery until the characteristic features...[Show more]
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