IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
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Pope, Samuel; Brandt, Eric; Mishra, Anil; Hogan, Simon; Zimmermann, Nives; Matthaei, Klaus; Foster, Paul S; Rothenberg, Marc E
Description
Background: IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown. Objective: We hypothesized that IL-13 - induced inflammatory changes in the lung were dependent in part on IL-5 and eotaxin, two eosinophil-selective cytokines. Methods: Recombinant murine IL-13 was repeatedly administered to the lung by intranasal delivery until the characteristic features...[Show more]
Collections | ANU Research Publications |
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Date published: | 2001 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/94127 |
Source: | Journal of Allergy and Clinical Immunology |
DOI: | 10.1067/mai.2001.118600 |
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01_Pope_IL-13_induces_eosinophil_2001.pdf | 736.24 kB | Adobe PDF | Request a copy |
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