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IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism

Pope, Samuel; Brandt, Eric; Mishra, Anil; Hogan, Simon; Zimmermann, Nives; Matthaei, Klaus; Foster, Paul S; Rothenberg, Marc E

Description

Background: IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown. Objective: We hypothesized that IL-13 - induced inflammatory changes in the lung were dependent in part on IL-5 and eotaxin, two eosinophil-selective cytokines. Methods: Recombinant murine IL-13 was repeatedly administered to the lung by intranasal delivery until the characteristic features...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/94127
Source: Journal of Allergy and Clinical Immunology
DOI: 10.1067/mai.2001.118600

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