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Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine cores

Wang, Gary; Chen, Yuanwei; Wang, Sheldon; Gentles, Andrew J; Sowin, Thomas; Kati, Warren; Muchmore, Steven; Giranda, Vincent; Stewart, Kent; Sham, Hing; Kempf, Dale; Laver, W. Graeme


The discovery of (±)-(2S,3R,4R)-2-(trifluoroacetamido)methyl-3-amino-1- (N′-ethyl-N′-isopropylcarbamyl)pyrrolidine-4-carboxylic acid (A-192558, 20e) as a potent inhibitor of influenza neuraminidase (NA) is described. Efficient syntheses of two core s

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm000468c


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