Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine cores
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Wang, Gary; Chen, Yuanwei; Wang, Sheldon; Gentles, Andrew J; Sowin, Thomas; Kati, Warren; Muchmore, Steven; Giranda, Vincent; Stewart, Kent; Sham, Hing; Kempf, Dale; Laver, W. Graeme
Description
The discovery of (±)-(2S,3R,4R)-2-(trifluoroacetamido)methyl-3-amino-1- (N′-ethyl-N′-isopropylcarbamyl)pyrrolidine-4-carboxylic acid (A-192558, 20e) as a potent inhibitor of influenza neuraminidase (NA) is described. Efficient syntheses of two core s
| Collections | ANU Research Publications |
|---|---|
| Date published: | 2001 |
| Type: | Journal article |
| URI: | http://hdl.handle.net/1885/94122 |
| Source: | Journal of Medicinal Chemistry |
| DOI: | 10.1021/jm000468c |
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| File | Description | Size | Format | Image |
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| 01_Wang_Design,_Synthesis,_and_2001.pdf | 457.3 kB | Adobe PDF | Request a copy |
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