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Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus

Mahalingam, Surendran; Karupiah, Gunasegaran; Takeda, Kiyoshi; Akira, Shizuo; Matthaei, Klaus; Foster, Paul S


We inoculated BALB/c mice deficient in STAT6 (STAT6-/-) and their wild-type (wt) littermates (STAT6+/+) with the natural mouse pathogen, ectromelia virus (EV). STAT6-/- mice exhibited increased resistance to generalized infection with EV when compared with STAT6+/+ mice. In the spleens and lymph nodes of STAT6-/- mice, T helper 1 (Th1) cytokines were induced at earlier time points and at higher levels postinfection when compared with those in STAT6+/+ mice. Elevated levels of NO were evident in...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.111151098


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