Mahalingam, Surendran; Karupiah, Gunasegaran; Takeda, Kiyoshi; Akira, Shizuo; Matthaei, Klaus; Foster, Paul S
We inoculated BALB/c mice deficient in STAT6 (STAT6-/-) and their wild-type (wt) littermates (STAT6+/+) with the natural mouse pathogen, ectromelia virus (EV). STAT6-/- mice exhibited increased resistance to generalized infection with EV when compared with STAT6+/+ mice. In the spleens and lymph nodes of STAT6-/- mice, T helper 1 (Th1) cytokines were induced at earlier time points and at higher levels postinfection when compared with those in STAT6+/+ mice. Elevated levels of NO were evident in...[Show more]
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