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Eosinophils promote allergic disease of the lung by regulating CD4(+) Th2 lymphocyte function

Mackenzie, Jason; Mattes, Joerg; Dent, Lindsay; Foster, Paul S


Eosinophils are primarily thought of as terminal effectors of allergic responses and of parasite elimination. However, limited studies suggest a more discrete immunomodulatory role for this leukocyte during these inflammatory responses. In this investigation, we highlight the potential of eosinophils to act as APCs and thus modulators of allergic responses by influencing Th2 cell function. In response to Ag provocation of the allergic lung, eosinophils rapidly trafficked to sites of Ag...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Immunology


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