Skip navigation
Skip navigation

Heterogeneity of functional GABA A receptors in rat dentate gyrus neurons revealed by a change in response to drugs during the whole-cell current time-course

Lim, Michelle; Birnir, Bryndis


We examined if the drug sensitivity of GABAA receptors in dentate gyrus granule neurons changed during the whole-cell current time-course. Effects of drugs on currents evoked immediately (the peak current) upon drug application and currents remaining about two seconds later (semi-plateau current) were compared. The apparent affinity for GABA (EC50) of the peak and the semi-plateau current were 14 and 4 μM, respectively. Bicuculline inhibited 50% of the peak and the semi-plateau current (IC50)...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Neuropharmacology
DOI: 10.1016/S0028-3908(01)00032-6


File Description SizeFormat Image
01_Lim_Heterogeneity_of_functional_2001.pdf172.64 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator