Heterogeneity of functional GABA A receptors in rat dentate gyrus neurons revealed by a change in response to drugs during the whole-cell current time-course
We examined if the drug sensitivity of GABAA receptors in dentate gyrus granule neurons changed during the whole-cell current time-course. Effects of drugs on currents evoked immediately (the peak current) upon drug application and currents remaining about two seconds later (semi-plateau current) were compared. The apparent affinity for GABA (EC50) of the peak and the semi-plateau current were 14 and 4 μM, respectively. Bicuculline inhibited 50% of the peak and the semi-plateau current (IC50)...[Show more]
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