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Heterogeneity of functional GABA A receptors in rat dentate gyrus neurons revealed by a change in response to drugs during the whole-cell current time-course

Lim, Michelle; Birnir, Bryndis

Description

We examined if the drug sensitivity of GABAA receptors in dentate gyrus granule neurons changed during the whole-cell current time-course. Effects of drugs on currents evoked immediately (the peak current) upon drug application and currents remaining about two seconds later (semi-plateau current) were compared. The apparent affinity for GABA (EC50) of the peak and the semi-plateau current were 14 and 4 μM, respectively. Bicuculline inhibited 50% of the peak and the semi-plateau current (IC50)...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/94116
Source: Neuropharmacology
DOI: 10.1016/S0028-3908(01)00032-6

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