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NMR structure of the N-terminal domain of E. coli DnaB helicase: implications for structure rearrangements in the helicase hexamer

Weigelt, Johan; Brown, Susan Elizabeth; Miles, Caroline; Dixon, Nicholas; Otting, Gottfried


Background: DnaB is the primary replicative helicase in Escherichia coli. Native DnaB is a hexamer of identical subunits, each consisting of a larger C-terminal domain and a smaller N-terminal domain. Electron-microscopy data show hexamers with C6 or C3 symmetry, indicating large domain movements and reversible pairwise association. Results: The three-dimensional structure of the N-terminal domain of E. coli DnaB was determined by nuclear magnetic resonance (NMR) spectroscopy. Structural...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Structure
DOI: 10.1016/S0969-2126(99)80089-6


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