Understanding the mechanism of B12-dependent methylmalonyl?CoA mutase: partial proton transfer in action
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Trebeck, Katherine; Golding, Bernard; Radom, Leo
Description
Ab initio molecular orbital theory is used to investigate several possible mechanisms involving free radical intermediates for the coenzyme- B12-dependent rearrangement catalyzed by methylmalonyl-CoA mutase. Our calculations suggest that an intermolecular pathway in which transient fragmentation of the substrate-derived radical is followed by recombination of the fragments ('fragmentation-recombination') is unlikely, but not out of the question. An alternative intramolecular pathway...[Show more]
Collections | ANU Research Publications |
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Date published: | 1999 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/93838 |
Source: | Journal of the American Chemical Society |
DOI: | 10.1021/ja991649a |
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