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An asymmetric synthesis of ADDA and ADDA-glycine dipeptide using the b-lactam synthon method

Cundy, Darren; Donohue, Anthony; McCarthy, Thomas D


The paper describes the synthesis of the W-Boc lactam 4, and demonstrates that it is an important intermediate in the synthesis of dipeptide 5 (X = H, n = 0, R = Me), an analogue of the ADDA-GIu dipeptide 3. In addition we have described a mild method for the preparation of the amino acid salt ADDA-HC1, and provided synthetic methods, and full characterisation for the previously 'elusive' free amino acid ADDA.

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Royal Chemical Society Journal Perkin Transactions


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