Sorimachi, Kenji; Naora, Hiroto; Akimoto, Kazumi; Niwa, Akira
Rat bone marrow-derived macrophages formed multinucleated giant cells spontaneously when cultured in slide glass chambers or when induced with the polyanion acetyl lignin. Nuclei in such cells tended to cluster in distinct rings. DNA fragmentation appeared to occur in multinucleated cells, as detected by 3' end-labeling. Southern blot analyses, using probes specific for nucleolar and non-nucleolar genes, indicated that chromatin DNA was fragmented whereas nucleolar DNA was relatively intact....[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.