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Multinucleation and preservation of nuclear integrity of macrophages

Sorimachi, Kenji; Naora, Hiroto; Akimoto, Kazumi; Niwa, Akira


Rat bone marrow-derived macrophages formed multinucleated giant cells spontaneously when cultured in slide glass chambers or when induced with the polyanion acetyl lignin. Nuclei in such cells tended to cluster in distinct rings. DNA fragmentation appeared to occur in multinucleated cells, as detected by 3' end-labeling. Southern blot analyses, using probes specific for nucleolar and non-nucleolar genes, indicated that chromatin DNA was fragmented whereas nucleolar DNA was relatively intact....[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Cell Biology International
DOI: 10.1006/cbir.1998.0266


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