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IDENTIFICATION OF NOVEL GLUTATHIONE TRANSFERASES AND POLYMORPHIC VARIANTS BY EXPRESSED SEQUENCE TAG DATABASE ANALYSIS

Board, Philip; Chelvanayagam, Gareth; Jermiin, Lars; Tetlow, Natasha; Tzeng, Huey-Fen; Anders, Michael; Blackburn, Anneke

Description

The human expressed sequence tag (EST) database can be searched by different sequence alignment strategies to identify new members of gene families and allelic variants. To illustrate the value of database analysis for gene discovery, we have focused on the glutathione S-transferase (GST) super family, an approach that has led to the identification of the Zeta class. The Zeta class GSTs catalyze the glutathione-dependent biotransformation of α-haloacids and the isomerization of...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/93199
Source: Drug Metabolism and Disposition

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