IDENTIFICATION OF NOVEL GLUTATHIONE TRANSFERASES AND POLYMORPHIC VARIANTS BY EXPRESSED SEQUENCE TAG DATABASE ANALYSIS
The human expressed sequence tag (EST) database can be searched by different sequence alignment strategies to identify new members of gene families and allelic variants. To illustrate the value of database analysis for gene discovery, we have focused on the glutathione S-transferase (GST) super family, an approach that has led to the identification of the Zeta class. The Zeta class GSTs catalyze the glutathione-dependent biotransformation of α-haloacids and the isomerization of...[Show more]
|Collections||ANU Research Publications|
|Source:||Drug Metabolism and Disposition|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.