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Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides

Wall, Dominic; Douglas, S; Ferro, Vito; Cowden, William; Parish, Christopher


In this study, 17 sulfated oligosaccharides were assessed by the activated partial thromboplastin time (APTT) test for their anticoagulant activity and nine were found to exhibit significant activity. Chain length, monosaccharide makeup, and linkage all appear to be critical factors in determining anticoagulant activity, with the most active compounds being five- to sixfold less potent than unfractionated heparin (UFH). Phosphomannopentaose sulfate (PI-88), one of the most active sulfated...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Thrombosis Research
DOI: 10.1016/S0049-3848(01)00314-0


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