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Targeting of EBNA1 for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+ T cell recognition

Tellam, Judy; Sherritt, Martina; Thomson, Scott; Tellam, R; Moss, Denis J; Burrows, Scott; Wiertz, E; Khanna, Rajiv


Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) includes a unique glycine-alanine repeat domain that inhibits the endogenous presentation of cytotoxic T lymphocyte (CTL) epitopes through the class I pathway by blocking proteasome-dependent degradation of this antigen. This immune evasion mechanism has been implicated in the pathogenesis of EBV-associated diseases. Here, we show that cotranslational ubiquitination combined with N-end rule targeting enhances the intracellular...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M104535200


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