Skip navigation
Skip navigation

Antiviral cytotoxic T cells cross-reactively recognize disparate peptide determinants from related viruses but ignore more similar self- and foreign determinants

Regner, Matthias; Lobigs, Mario; Blanden, Robert; Milburn, Peter J; Mullbacher, Arno


We have investigated the reactivities of cytotoxic T (Tc) cells against the two immunodominant, H-2Kk-restricted determinants from the Flavivirus Murray Valley encephalitis virus (MVE), MVE1785 (REHSGNEI) and MVE1971 (DEGEGRVI). The respective Tc cell populations cross-reactively lysed target cells pulsed with determinants from the MVE1785- and MVE1971-corresponding positions of six other flaviviruses, despite low sequence homology in some cases. Notably, anti-MVE1785 Tc cells recognized a...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Immunology


File Description SizeFormat Image
01_Regner_Antiviral_cytotoxic_T_cells_2001.pdf814.8 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator