Virulence of mousepox is independent of serpin-mediated control of cellular cytotoxicity
We have investigated whether the differential virulence seen of two Ectromelia (Ect) strains, EctMoscow and EctHampstead egg, is due to mutation or differential regulation of their serpins (SPI). Poxvirus encoded serine proteinase inhibitors (serpins) have been shown to interfere with cytolytic activity of leukocytes and can also determine virulence. We show that the deduced amino acid sequences of SPI-1, 2, and 3 are identical for the highly virulent EctMoscow and the low virulent EctHampstead...[Show more]
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