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Prime-boost immunization generates a high frequency, high-avidity CD8+ cytotoxic T lymphocyte population

Estcourt, Marie; Ramsay, R; Brooks, A; Thomson, Scott; Medveczky, C; Ramshaw, Ian


Development and expansion of high-avidity T cell populations may be important for the success of immunization strategies against HIV and other pathogens that have presented major problems for vaccine development. We have used tetrameric-MHC complexes ex vivo and lytic assays to show that 'prime-boost' immunization with DNA vaccines and recombinant poxvirus vectors generates high frequencies of cytotoxic T lymphocytes (CTL) that recognize target cells expressing very low levels of specific...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: International Immunology


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