Hindmarsh, Elizabeth; Staykova, Maria; Willenborg, D; Parish, Christopher
Phosphosugars, such as mannose-6-phosphate (M6P), have been shown previously to display anti-inflammatory properties, notably inhibition of experimental autoimmune encephalomyelitis (EAE) and adjuvant-induced arthritis in rats. It has been proposed that M6P exerts its anti-inflammatory effect by displacing lysosomal enzymes, which are involved in T-cell extravasation into inflammatory sites, from the 300 kDa mannose-6-phosphate receptor (MPR-300) on the surface of T cells. If this model is...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.