Cell surface expression of the 300 kDa mannose-6-phosphate receptor by activated T lymphocytes
Phosphosugars, such as mannose-6-phosphate (M6P), have been shown previously to display anti-inflammatory properties, notably inhibition of experimental autoimmune encephalomyelitis (EAE) and adjuvant-induced arthritis in rats. It has been proposed that M6P exerts its anti-inflammatory effect by displacing lysosomal enzymes, which are involved in T-cell extravasation into inflammatory sites, from the 300 kDa mannose-6-phosphate receptor (MPR-300) on the surface of T cells. If this model is...[Show more]
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