Skip navigation
Skip navigation

Continual low-level activation of the classical complement pathway

Manderson, A; Pickering, Mark; Botto, Marina; Walport, Mark J; Parish, Christopher


There is evidence that the classical complement pathway may be activated via a "C1-tickover" mechanism, analogous to the C3-tickover of the alternative pathway. We have quantitated and characterized this pathway of complement activation. Analysis of freshly collected mouse and human plasma revealed that spontaneous C3 activation rapidly occurred with the generation of C3 fragments in the plasma. By the use of complement- and Ig-deficient mice it was found that C1q, C4, C2, and plasma Ig were...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.194.6.747


File Description SizeFormat Image
01_Manderson_Continual_low-level_activation_2001.pdf136.95 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator