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The Synthesis and Tubulin Binding Activity of Thiophene-Based Analogues of Combretastatin A-4

Flynn, Bernard; Flynn, Guy; Hamel, Ernest; Jung, M Katherine


A number of analogues of combretastatin A-4 (1), containing a thiophene ring interposed between the two phenyl groups, have been prepared. The synthesis of these compounds employed a combination of palladium-mediated coupling and iodocyclization techniques. The thiophene compounds 11, 14, 18, and 19 also represent non-benzofused analogues of some recently described tubulin binding benzo[b]thiophenes 3-5. The most active thiophene compounds identified in this study were 11, 14, and 18. Overall...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Bioorganic and Medicinal Chemistry Letters
DOI: 10.1016/S0960-894X(01)00436-X


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