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Testing for the presence of cured patients: a simulation study

Peng, Paul Yingwei; Dear, Keith; Carriere, K


An important but difficult problem in clinical trials is to determine the presence of cured patients when long-term survivors are observed. The likelihood ratio test has been studied for this purpose in the gamma mixture model. However, its asymptotic null distribution is not readily available due to a violation of boundary conditions in the standard asymptotic theory. In this paper, a simulation study is employed to examine a proposed asymptotic null distribution of the likelihood ratio test....[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Statistics in Medicine
DOI: 10.1002/sim.781


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