Skip navigation
Skip navigation

A pathological function for eotaxin and eosinphils in eosinphilic gastrontestinal inflammation

Hogan, Simon P; Mishra, Anil; Brandt, Eric; Royalty, Michael; Pope, Samuel; Zimmermann, Nives; Foster, Paul S; Rothenberg, Marc E

Description

Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine model of oral antigen-induced eosinophil-associated gastrointestinal disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils. Exposure of mice to enteric-coated antigen promotes an extensive T helper 2-associated eosinophilic inflammatory response involving the esophagus, stomach,...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/92910
Source: Nature Immunology
DOI: 10.1038/86365

Download

There are no files associated with this item.


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator