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A pathological function for eotaxin and eosinphils in eosinphilic gastrontestinal inflammation

Hogan, Simon P; Mishra, Anil; Brandt, Eric; Royalty, Michael; Pope, Samuel; Zimmermann, Nives; Foster, Paul S; Rothenberg, Marc E


Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine model of oral antigen-induced eosinophil-associated gastrointestinal disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils. Exposure of mice to enteric-coated antigen promotes an extensive T helper 2-associated eosinophilic inflammatory response involving the esophagus, stomach,...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Nature Immunology
DOI: 10.1038/86365


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