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Characteristics of Irreversible ATP Activation Suggest that Native Skeletal Ryanodine Receptors Can Be Phosphorylated via an Endogenous CaMKII

Dulhunty, Angela; Laver, Derek Rowland; Curtis, Suzanne; Pace, Suzy M; Haarmann, Claudia; Gallant, Esther


Phosphorylation of skeletal muscle ryanodine receptor (RyR) calcium release channels by endogenous kinases incorporated into lipid bilayers with native sarcoplasmic reticulum vesicles was investigated during exposure to 2 mM cytoplasmic ATP. Activation of RyRs after 1-min exposure to ATP was reversible upon ATP washout. In contrast, activation after 5 to 8 min was largely irreversible: the small fall in activity with washout was significantly less than that after brief ATP exposure. The...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Biophysical Journal


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