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The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator

Dulhunty, Angela; Gage, Peter; Curtis, Suzanne; Chelvanayagam, Gareth; Board, Philip


The ubiquitous glutathione transferases (GSTs) catalyze glutathione conjugation to many compounds and have other diverse functions that continue to be discovered. We noticed sequence similarities between Omega class GSTs and a nuclear chloride channel, NCC27 (CLIC1), and show here that NCC27 belongs to the GST structural family. The structural homology prompted us to investigate whether the human Omega class glutathione transferase GSTO1-1 forms or modulates ion channels. We find that GSTO1-1...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M007874200


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