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Histone variant H2A.Z is required for early mammalian development

Faast, Renate; Thonglairoam, Varaporn; Schulz, Thomas C; Beall, Jacquie; Wells, Julian; Taylor, Helen; Matthaei, Klaus; Rathjen, Peter D; Tremethick, David; Lyons, Ian

Description

Fundamental to the process of mammalian development is the timed and coordinated regulation of gene expression. This requires transcription of a precise subset of the total complement of genes. It is clear that chromatin architecture plays a fundamental role in this process by either facilitating or restricting transcription factor binding [1]. How such specialized chromatin structures are established to regulate gene expression is poorly understood. All eukaryotic organisms contain specialized...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/92889
Source: Current Biology
DOI: 10.1016/S0960-9822(01)00329-3

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