Histone variant H2A.Z is required for early mammalian development
Fundamental to the process of mammalian development is the timed and coordinated regulation of gene expression. This requires transcription of a precise subset of the total complement of genes. It is clear that chromatin architecture plays a fundamental role in this process by either facilitating or restricting transcription factor binding . How such specialized chromatin structures are established to regulate gene expression is poorly understood. All eukaryotic organisms contain specialized...[Show more]
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