Interleukin-5 and eosinphils as therapeutic targets for asthma
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Foster, Paul S; Hogan, Simon; Yang, Ming; Mattes, Joerg; Young, Ian; Matthaei, Klaus; Kumar, Rakesh K; Mahalingam, Surendran; Webb, Dianne
Description
Extensive clinical investigations have implicated eosinophils in the pathogenesis of asthma. In a recent clinical trial, humanized monoclonal antibody to interleukin (IL)-5 significantly limited eosinophil migration to the lung. However, treatment did not affect the development of the late-phase response or airways hyperresponsiveness in experimental asthma. Although IL-5 is a key regulator of eosinophilia and attenuation of its actions without signs of clinical improvement raises questions...[Show more]
Collections | ANU Research Publications |
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Date published: | 2002 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/92884 |
Source: | Trends in Molecular Medicine |
DOI: | 10.1016/S1471-4914(02)02302-X |
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01_Foster_Interleukin-5_and_eosinphils_2002.pdf | 272.2 kB | Adobe PDF | Request a copy |
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