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Interleukin-5 and eosinphils as therapeutic targets for asthma

Foster, Paul S; Hogan, Simon; Yang, Ming; Mattes, Joerg; Young, Ian; Matthaei, Klaus; Kumar, Rakesh K; Mahalingam, Surendran; Webb, Dianne

Description

Extensive clinical investigations have implicated eosinophils in the pathogenesis of asthma. In a recent clinical trial, humanized monoclonal antibody to interleukin (IL)-5 significantly limited eosinophil migration to the lung. However, treatment did not affect the development of the late-phase response or airways hyperresponsiveness in experimental asthma. Although IL-5 is a key regulator of eosinophilia and attenuation of its actions without signs of clinical improvement raises questions...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/92884
Source: Trends in Molecular Medicine
DOI: 10.1016/S1471-4914(02)02302-X

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