B lymphocytes not required for progression from insulitis to diabetes in non-obese diabetic mice
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Charlton, Brett; Da Zhang, Ming; Slattery, Robyn
Description
Previous studies have implicated B lymphocytes in the pathogenesis of diabetes in the non-obese diabetic (NOD) mouse. While it is clear that B lymphocytes are necessary, it has not been clear at which stage of disease they play a role; early, late or both. To clarify when B lymphocytes are needed, T lymphocytes were transferred from 5-week-old NOD female mice to age-matched NOD/severe combined immunodeficiency (SCID) recipient mice. NOD/SCID mice, which lack functionally mature T and B...[Show more]
Collections | ANU Research Publications |
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Date published: | 2001 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/92882 |
Source: | Immunology and Cell Biology |
DOI: | 10.1046/j.1440-1711.2001.01045.x |
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01_Charlton_B_lymphocytes_not_required_for_2001.pdf | 235.01 kB | Adobe PDF | Request a copy |
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