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Structural Determinants for Activation or Inhibition of Ryanodine Receptors by Basis Residues in the Dihydropyridine Receptor II-III Loop

Casarotto, Marco; Green, Daniel; Pace, Suzy M; Curtis, Suzanne; Dulhunty, Angela


The structures of peptide A, and six other 7-20 amino acid peptides corresponding to sequences in the A region (Thr671-Leu690) of the skeletal muscle dihydropyridine receptor II-III loop have been examined, and are correlated with the ability of the peptides to activate or inhibit skeletal ryanodine receptor calcium release channels. The peptides adopted either random coil or nascent helix-like structures, which depended upon the polarity of the terminal residues as well as the presence and...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Biophysical Journal


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