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A NF-kB/Sp1 Region Is Essential for Chromatin Remodeling and Correct Transcription of a Human Granulocyte-Macrophage Colony-Stimulating Factor Transgene

Cakouros, Dimitrios; Cockerill, Peter; Bert, Andrew; Mital, Renu; Roberts, David W; Shannon, M Frances

Description

The GM-CSF gene is expressed following activation of T cells. The proximal promoter and an upstream enhancer have previously been characterized using transfection and reporter assays in T cell lines in culture. A 10.5-kb transgene containing the entire human GM-CSF gene has also been shown to display inducible, position-independent, copy number-dependent transcription in mouse splenocytes. To determine the role of individual promoter elements in transgene function, mutations were introduced...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/92878
Source: Journal of Immunology

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