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Ring Flexibility within Tricyclic Antidepressant Drugs

Casarotto, Marco; Craik, David J


The internal flexibility of the central seven-membered ring of a series of tricyclic antidepressant drugs (TCAs), imipramine {1}, amitriptyline{2}, doxepin {3}, and dothiepin {4}, has been investigated by 1H and 13C nuclear magnetic (NMR) techniques. Two

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Pharmaceutical Sciences
DOI: 10.1002/jps.1027


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