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Stat6 dependent goblet cell hyperplasia during intestinal nematode infection

Khan, W; Blennerhasset, P; Ma, C; Matthaei, Klaus; Collins, Stephen Frederick


To identify the role of signal transducer and activator of transcription factor 6 (Stat6) in the development of intestinal goblet cell hyperplasia during nematode infection, we compared the number of goblet cells in Stat6 deficient (Stat6 -/-) mice with that generated in wild-type (Stat6 +/+) mice in Trichinella spiralis infection. The number of goblet cells significantly increased with infection in wild-type mice. However, Stat6 -/- failed to generate infection-induced goblet cell hyperplasia...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Parasite Immunology
DOI: 10.1046/j.1365-3024.2001.00353.x


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