Discovery and structure of a potent and highly specific blocker of insect calcuim channels
Wang, Xiu-hong; Connor, Mark; Wilson, David; Wilson, Harry; Nicholson, Graham; Smith, Ross; Shaw, Denis; Mackay, Joel Peter; Alewood, Paul F; Christie, Macdonald J; King, Glenn
Description
We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak...[Show more]
Collections | ANU Research Publications |
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Date published: | 2001 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/92818 |
Source: | Journal of Biological Chemistry |
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01_Wang_Discovery_and_structure_of_a_2001.pdf | 984.84 kB | Adobe PDF | Request a copy |
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