Wang, Xiu-hong; Connor, Mark; Wilson, David; Wilson, Harry; Nicholson, Graham; Smith, Ross; Shaw, Denis; Mackay, Joel Peter; Alewood, Paul F; Christie, Macdonald J; King, Glenn
We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak...[Show more]
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