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Nuclear Transport of Parathyroid Hormone (PTH)-Related Protein is Dependent on Microtubules

Lam, Mark H C; Thomas, Rachel; Loveland, Kate; Schilders, Steven; Gu, Min; Martin, Jenny; Gillespie, M T; Jans, David A

Description

PTH-related protein (PTHrP) was first discovered as a circulating factor secreted by certain cancers and is responsible for the syndrome of humoral hypercalcemia of malignancy induced by various tumors. The similarity of its N terminus to that of PTH enables PTHrP to share the signaling properties of PTH, but the rest of the molecule possesses distinct functions, including a role in the nucleus/nucleolus in reducing apoptosis and enhancing cell proliferation. PTHrP nuclear import is mediated by...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/92799
Source: Molecular Endocrinology
DOI: 10.1210/me.16.2.390

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