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Gene Targeting of Desrt, a Novel ARID Class DNA-Binding Protein, Causes Growth Retardation and Abnormal Development of Reproductive Organs

Lahoud, Mireille; Ristevski, Sika; Venter, Deon; Jermiin, Lars; Bertoncello, Ivan; Zavarsek, Silva; Hasthorpe, Sue; Drago, John; de Kretser, David M; Hertzog, Paul; Kola, Ismail

Description

We have cloned and characterized a novel murine DNA-binding protein Desrt, with a motif characteristic of the ARID (A-T rich interaction domain) family of transcription factors. The Desrt gene encodes an 83-kD protein that is shown to bind DNA and is widely expressed in adult tissues. To examine the in vivo function of Desrt, we have generated mice with a targeted mutation in the ARID domain of Desrt. Homozygous mutants have reduced viability, pronounced growth retardation, and a high incidence...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/92659
Source: Genome Research
DOI: 10.1101/gr.168801

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