Gene Targeting of Desrt, a Novel ARID Class DNA-Binding Protein, Causes Growth Retardation and Abnormal Development of Reproductive Organs
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Lahoud, Mireille; Ristevski, Sika; Venter, Deon; Jermiin, Lars; Bertoncello, Ivan; Zavarsek, Silva; Hasthorpe, Sue; Drago, John; de Kretser, David M; Hertzog, Paul; Kola, Ismail
Description
We have cloned and characterized a novel murine DNA-binding protein Desrt, with a motif characteristic of the ARID (A-T rich interaction domain) family of transcription factors. The Desrt gene encodes an 83-kD protein that is shown to bind DNA and is widely expressed in adult tissues. To examine the in vivo function of Desrt, we have generated mice with a targeted mutation in the ARID domain of Desrt. Homozygous mutants have reduced viability, pronounced growth retardation, and a high incidence...[Show more]
Collections | ANU Research Publications |
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Date published: | 2001 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/92659 |
Source: | Genome Research |
DOI: | 10.1101/gr.168801 |
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01_Lahoud_Gene_Targeting_of_Desrt,_a_2001.pdf | 694.09 kB | Adobe PDF | Request a copy |
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