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Vitreal dihydroxyphenylacetic acid (DOPAC) as an index of retinal dopamine release

Megaw, Pamela; Morgan, Ian; Boelen, Mary


Dopamine is generally accepted as a major neurotransmitter associated with light-adaptive processes in the retina. However, tittle is known about its precise release pattern in vivo, largely due to the lack of an unambiguous method for the determination of dopamine release. We have found that vitreal levels of dihydroxyphenylacetic acid (DOPAC) reflect the rate of dopamine release in chickens. Blocking re-uptake with nomifensine significantly lowered vitreal DOPAC and retinal dopamine,...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Neurochemistry
DOI: 10.1046/j.1471-4159.2001.00145.x


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