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Stereocontrolled synthesis of deuterated phenylalanine derivatives through manipulation of an N -phthaloyl protecting group for the recall of stereochemistry. Application in the study of phenylalanine ammonia lyase

Easton, Christopher; Fryer, Nicholas; Kelly, James; Kociuba, Katherine

Description

The enantiomers of [2-2(H1]phenylalanine and all four stereoisomers of [2,3-2H2]phenylalanine) have been prepared from (S)-phenylalanine through the introduction of a chiral centre onto an N-phthaloyl protecting group for the recall of stereochemistry. Studies of the interaction of these labelled phenylalanines with (S)-phenylalanine ammonia lyase show that both the C-2 and C-3 hydrogens of the product trans-cinnamate undergo exchange with solvent in the presence of the enzyme. The mechanistic...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/92610
Source: ARKIVOC

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