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Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation

Usacheva, A; Sandoval, R; Domanski, Paul; Kotenko, S; Nelms, Keats; Goldsmith, M; Colamonici, O

Description

Kinases of the Jak family (Jak1/2/3 and Tyk2) interact with the membrane proximal domain of different cytokine receptors and play a critical role in the activation of cytokine and growth factor signaling pathways. In this report we demonstrate that both the Box 1 and Box 2 motif collaborate in the association and activation of Jak1 by type I interferons. Mutational analysis of the β chain of type I interferon receptor (IFNαRβL/IFNAR2) revealed that Box 1 plays a more significant role in...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/92583
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M205757200

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