Usacheva, A; Sandoval, R; Domanski, Paul; Kotenko, S; Nelms, Keats; Goldsmith, M; Colamonici, O
Kinases of the Jak family (Jak1/2/3 and Tyk2) interact with the membrane proximal domain of different cytokine receptors and play a critical role in the activation of cytokine and growth factor signaling pathways. In this report we demonstrate that both the Box 1 and Box 2 motif collaborate in the association and activation of Jak1 by type I interferons. Mutational analysis of the β chain of type I interferon receptor (IFNαRβL/IFNAR2) revealed that Box 1 plays a more significant role in...[Show more]
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