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Nitric oxide donors selectively potentiate thrombin-stimulated p70(S6k) activity and morphological changes in swiss 3T3 cells

Berven, Leise; Frew, I; Crouch, Michael F


Thrombin stimulates both DNA synthesis and cell morphological changes in Swiss 3T3 cells, although the mechanism of signal coordination leading to these responses is unknown. We report here that nitric oxide (NO) donors selectively enhance thrombin-stimulated p70(S6k) activity by 40-60%, an effect that was sustained for 24 h. Potentiation of p70(S6k) also was observed with cGMP analogues indicating that this effect is mediated by cGMP-activated protein kinase. NO donors also induced...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Biochemical and Biophysical Research Communications
DOI: 10.1006/bbrc.1999.1833


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