Differential mRNA expression and subcellular locations of P13-kinase isoforms in sympathetic and sensory neurons
Phosphatidylinositol 3-kinase (PI3-kinase) enzymes are key signalling molecules in the PC12 and neuronal cell survival pathway and are also involved in the regulation of retrograde axonal transport of nerve growth factor (NGF), with sympathetic neurons more sensitive to the effects of wortmannin/LY294002 than sensory neurons (Bartlett et al. ; Brain Res. 761:257-262; Reynolds et al.  Brain Res. 798:6774). In this article, we characterized the mRNA expression of PI3-kinase isoforms...[Show more]
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|Source:||Journal of Neuroscience Research|
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