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A novel presynaptic inhibitory mechanism underlies paired pulse depression at a fast central synapse

Bellingham, Mark C.; Walmsley, Bruce


Several distinct mechanisms may cause synaptic depression, a common form of short-term synaptic plasticity. These include postsynaptic receptor desensitization, presynaptic depletion of releasable vesicles, or other presynaptic mechanisms depressing vesicle release. At the endbulb of Held, a fast central calyceal synapse in the auditory pathway, cyclothiazide (CTZ) abolished marked paired pulse depression (PPD) by acting presynaptically to enhance transmitter release, rather than by blocking...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Neuron
DOI: 10.1016/S0896-6273(00)80762-X


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