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The Ubp6 family of deubiquitinating enzymes contains a ubiquitin-like domain: SUb

Wyndham, A; Baker, Rohan; Chelvanayagam, Gareth


A sequence motif that is similar to Ubiquitin (SUb) has been identified in the Saccharomyces cerevisiae ubiquitin-specific protease Ubp6. SUb is conserved in all known Ubp6 homologues from a spectrum of eukaryotic species and is also present in a group of hypothetical proteins of unknown function (Unk1-3) present in sequence databases. An N-terminal deletion mutant of Ubp6 that lacks SUb is still capable of cleaving α-linked ubiquitin fusions, suggesting that SUb forms a separate domain to the...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Protein Science


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