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Characterization and chromosomal localization of USP3, a novel human ubiquitin-specific protease

Sloper-Mould, K; Eyre, Helen; Wang, Xiao Wen; Sutherland, Grant; Baker, Rohan


Conjugation to the small eukaryotic protein ubiquitin can functionally modify or target proteins for degradation by the proteasome. Removal of the ubiquitin modification, or deubiquitination, is performed by ubiquitin- specific proteases and is an important mechanism regulating this pathway. Here we describe a novel human ubiquitin-specific protease, USP3, initially identified as a partial cDNA clone similar to one of two highly conserved sequence regions common to all ubiquitin-specific...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Biological Chemistry
DOI: 10.1074/jbc.274.38.26878


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