Growing up on the streets: why B-cell development differs from T-cell development
B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.
|Collections||ANU Research Publications|
|Source:||Trends in Immunology|
|01_Weintraub_Growing_up_on_the_streets:_why_1999.pdf||279.89 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.