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Growing up on the streets: why B-cell development differs from T-cell development

Weintraub, Bennet C.; Goodnow, Christopher


B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Trends in Immunology
DOI: 10.1016/S0167-5699(98)01440-6


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