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A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor

Dang, J; Boyd, Douglas; Allgayer, H; Doe, W; Wang, Yang


An 8.5-kb 5'-flanking region of the human urokinase-type plasminogen activator receptor (uPAR) gene was cloned and the detailed uPAR promoter region defined in an 188-bp fragment between bases -141 and +47 relative to the transcription-start site. 5;-Deletion to - 100 and -60 in the region abolished its promoter activity, indicating that an 81-bp segment between - 141 and -61, which contains a proximal AP-1 site at position -70, is required for uPAR promoter activity. Nuclear extracts from...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: European Journal of Biochemistry
DOI: 10.1046/j.1432-1327.1999.00583.x


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