Experimental melanin-induced uveitis in the Fischer 344 rats is inhibited by anti-CD4 monoclonal antibody, but not by mannose-6-phosphate
Experimental melanin-induced uveitis (EMIU) is a rodent model of acute anterior uveitis which was described in 1993. We investigated strain susceptibility, and age and gender characteristics of the model, undertook histological and immunohistochemical studies to investigate underlying cellular mechanisms, and examined several treatment options. Rats were immunized with bovine ocular melanin (250 μg), and disease was followed by slit lamp examination. Lewis, Fischer 344 and Porton rats were...[Show more]
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|Source:||Clinical and Experimental Immunology|
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