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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

Mullbacher, Arno; Waring, Paul; Tha Hla, Ron; Tran, Thao (Thomas); Chin, S; Stehle, Thomas; Museteanu, Crisan; Simon, Markus M

Description

Analysis of perforin-deficient mice has identified the cytolytic pathway and perforin as the preeminent effector molecule in T cell-mediated control of virus infections. In this paper, we show that mice lacking both granzyme A (gzmA) and granzyme B (gzmB), which are, beside perforin, key constituents of cytolytic vesicles, are as incapable as are perforin-deficient mice of controlling primary infections by the natural mouse pathogen ectromelia, a poxvirus. Death of gzmA x gzmB double knockout...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
URI: http://hdl.handle.net/1885/92491
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.96.24.13950

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