Mullbacher, Arno; Waring, Paul; Tha Hla, Ron; Tran, Thao (Thomas); Chin, S; Stehle, Thomas; Museteanu, Crisan; Simon, Markus M
Analysis of perforin-deficient mice has identified the cytolytic pathway and perforin as the preeminent effector molecule in T cell-mediated control of virus infections. In this paper, we show that mice lacking both granzyme A (gzmA) and granzyme B (gzmB), which are, beside perforin, key constituents of cytolytic vesicles, are as incapable as are perforin-deficient mice of controlling primary infections by the natural mouse pathogen ectromelia, a poxvirus. Death of gzmA x gzmB double knockout...[Show more]
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