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Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infection

Mullbacher, Arno; Lobigs, Mario; Yewdell, Jonathan W; Bennink, Jack R; Tha Hla, Ron; Blanden, Robert

Description

Vaccinia virus (VV)-encoded MHC class I K(d) molecules which differ by a single amino acid change from glutamine (K(dw), wild type) to histidine (K(dm), mutant) at position 114 located in the floor of the peptide binding groove were compared in terms of peptide binding and cytotoxic T (Tc) cell recognition. Most anti-viral Tc cells were nor affected or only marginally affected. However, the K(dm) molecule did not detectably present the immunodominant peptide (NPP147-155) of influenza virus...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
URI: http://hdl.handle.net/1885/92490
Source: European Journal of Immunology

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