Mullbacher, Arno; Lobigs, Mario; Yewdell, Jonathan W; Bennink, Jack R; Tha Hla, Ron; Blanden, Robert
Vaccinia virus (VV)-encoded MHC class I K(d) molecules which differ by a single amino acid change from glutamine (K(dw), wild type) to histidine (K(dm), mutant) at position 114 located in the floor of the peptide binding groove were compared in terms of peptide binding and cytotoxic T (Tc) cell recognition. Most anti-viral Tc cells were nor affected or only marginally affected. However, the K(dm) molecule did not detectably present the immunodominant peptide (NPP147-155) of influenza virus...[Show more]
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