Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections
Previous observations that the highly conserved poxvirus-encoded serpins inhibit cytotoxic activities of alloreactive CTL via granule and/or Fas- mediated pathways was taken to indicate their involvement in immune evasion by poxviruses. We now show that interference with 51Cr release from target cells by ectromelia and cowpoxvirus is limited to alloreactive but not MHC- restricted CTL. The data are in support of the paramount importance of CTL and its effector molecule perforin in the recovery...[Show more]
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|Source:||Journal of Immunology|
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