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Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin

Hayder, H; Blanden, Robert; Korner, Heinrich; Riminton, D Sean; Sedgwick, Jonathon; Mullbacher, Arno


Mice infected with an adenovirus mutant in which the E3 region is deleted, including TNF-resistance genes, develop fatal liver pathology within 3-4 days after infection. At least 10-fold more wild-type virus was needed to cause comparable pathology. These results indicate that the E3 region is critically involved in modulating the pathogenesis of adenovirus infection and that TNF may play a role in liver damage. To explore the latter possibility, the course of disease was examined in infected...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Immunology


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