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Inhibition of Allergic Airway Inflammation in Mice Lacking Nitric Oxide Synthase 21

Xiong, Y; Karupiah, Gunasegaran; Hogan, Simon; Foster, Paul S; Ramsay, Alistair


We have used mice rendered deficient for nitric oxide synthase 2 (NOS2) production to study the role of inducible nitric oxide (NO) in the pathogenesis of allergic airways disease. Using a model with OVA as aeroallergen, we show that the manifestations of disease, including infiltration of inflammatory cells, particularly eosinophils, loss of structural integrity of the airway walls, microvascular leakage, pulmonary edema, and airway occlusion are markedly less severe in the NOS2 mutants than...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Immunology


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