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Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte macrophage-colony stimulating factor promoter

Shang, Catherine; Attema, Joanne; Cakouros, Dimitrios; Cockerill, Peter; Shannon, M Frances


The granulocyte macrophage colony stimulating factor (GM-CSF) promoter contains a 10 bp element known as CK-1 or CD28RE that specifically responds to the co-stimulatory signal delivered to T cells via the CD28 surface receptor. This element is a variant NFκB site that does not function alone but requires an adjacent promoter region that includes a classical NFκB element, an Sp-1 site and a putative activator protein-1 (AP-1)-like binding site. The entire region is referred to as the CD28...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: International Immunology


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